pfizer's Coronavirus Vaccine Ingredients
Pfizers Covid 19 Vaccine Ingredients :
mRNA (Needs it's own page).
Lipids including,
4-hydroxybutyl : (Possible cyanide poisoning, see picture at the bottom)
Product Name: 4-fluoro MDMB-BUTINACA N-(4-hydroxybutyl) metabolite
Classification of the Substance or Mixture:
Flammable Liquids, Category 2
Acute Toxicity: Inhalation, Category 4
Acute Toxicity: Oral, Category 4
Acute Toxicity: Skin, Category 4
Serious Eye Damage/Eye Irritation, Category 2
H225: Highly flammable liquid and vapor.
H302: Harmful if swallowed.
H312: Harmful in contact with skin.
H319: Causes serious eye irritation.
H332: Harmful if inhaled.
P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302+352: IF ON SKIN: Wash with plenty of soap and water.
P303+361+353: IF ON SKIN (or hair): Remove/take off immediately all contaminated clothing. Rinse skin with water/shower.
P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P330: Rinse mouth.
P337+313: If eye irritation persists, get medical advice/attention.
P362+364: Take off contaminated clothing and wash it before reuse
Also contains Acetonitrile (99.0%) (4-fluoro MDMB-BUTINACA N-(4-hydroxybutyl)
metabolite 0.1%)
Acetonitrile is metabolized to cyanide. Patients with significant exposures must be observed for signs of cyanide poisoning and treated accordingly. -https://www.caymanchem.com/msdss/26857m.pdf
Adverse Human Health
Effects and Symptoms
Can cause fatal cyanide poisoning.
Causes serious eye irritation.
Harmful if swallowed, inhaled, or absorbed through the skin.
Material may be irritating to the mucous membranes and upper respiratory tract.
May be fatal if swallowed, inhaled, or absorbed through the skin.
May cause skin or respiratory system irritation.
Several hours may elapse from exposure to onset of symptoms.
To the best of our knowledge, the toxicological properties have not been thoroughly investigated
All above from https://www.caymanchem.com/msdss/26857m.pdf
hexane-6,1-diyl :
Reproductive/Developmental Effects:
No information is available on the reproductive or developmental effects of hexane in humans.
Testicular damage has been observed in male rats exposed to hexane via inhalation.
Teratogenic effects were not observed in the offspring of rats chronically exposed via inhalation in several studies. (3,5,8)
https://www.epa.gov/sites/production/files/2016-09/documents/hexane.pdf
Realistically Hexane in small doses is one of the safer ingredients.
2-hexyldecanoate :
(Product name : Ascorbyl tetra-2-hexyldecanoate)
Not a hazardous substance or mixture according to the Globally Harmonized System (GHS) - https://labchem-wako.fujifilm.com/sds/W01W0101-1959JGHEEN.pdf
(though they also say if ingested, call a physician or poison control center immediately).
Hazard statement(s)
H317 May cause an allergic skin reaction
H410 Very toxic to aquatic life with long lasting effects
In conclusion, there is not much data on this substance.
Poly(ethylene glycol) MW 2000 :
(Polyethylene glycol 2000 / PEG 2000)
It is noticed the current research demonstrated the moderate cytotoxicity of PEG-1000 and PEG-4000 to L929 cells, and the nearly non-cytotoxicity of PEG-400 and PEG-2000
https://pubs.rsc.org/en/content/articlehtml/2017/ra/c7ra00861a
Depending on manufacturing processes, PEGs may be contaminated with measurable amounts of ethylene oxide and 1,4-dioxane. i The International Agency for Research on Cancer classifies ethylene oxide as a known human carcinogen and 1,4-dioxane as a possible human carcinogen. Ethylene oxide can also harm the nervous system ii and the California Environmental Protection Agency has classified it as a developmental toxicant based on evidence that it may interfere with human development. iii 1,4-dioxane is also persistent. In other words, it doesn’t easily degrade and can remain in the environment long after it is rinsed down the shower drain. 1,4-dioxane can be removed from cosmetics during the manufacturing process by vacuum stripping, but there is no easy way for consumers to know whether products containing PEGs have undergone this process.
While carcinogenic contaminants are the primary concern, PEG compounds themselves show some evidence of genotoxicity vi,vii and if used on broken skin can cause irritation and systemic toxicity. The industry panel that reviews the safety of cosmetics ingredients concluded that some PEG compounds are not safe for use on damaged skin (although the assessment generally approved of the use of these chemicals in cosmetics). ix Also, PEG functions as a “penetration enhancer,” increasing the permeability of the skin to allow greater absorption of the product — including harmful ingredients.
Propylene glycol is a related chemical that, like PEGs, functions as a penetration enhancer and can allow harmful ingredients to be absorbed more readily through the skin. It can also cause allergic reactions. Health Canada categorized propylene glycol as a “moderate human health priority” and flagged it future assessment under the government’s Chemicals Management Plan.
Other ethoxylates may be contaminated with ethylene oxide and 1,4-dioxane. These ingredients usually have chemical names including the letters “eth” (e.g., polyethylene glycol).
https://davidsuzuki.org/queen-of-green/dirty-dozen-peg-compounds-contaminants/#:~:text=Depending%20on%20manufacturing%20processes%2C%20PEG,and%201%2C4%2Ddioxane.&text=The%20International%20Agency%20for%20Research,as%20a%20possible%20human%20carcinogen.
Ethoxylation is the process of reacting ethylene oxide with other chemicals to make them less harsh. Ethoxylation can create small amounts of 1,4-dioxane and leave residual ethylene oxide in the product.
This manufacturing process can result in two toxic contaminants linked to breast cancer and other cancers: ethylene oxide and 1,4-dioxane.
Ethoxylated ingredients are generally of low concern on their own. However, they can be contaminated with ethylene oxide, a known carcinogen,and 1,4- dioxane, reasonably anticipated to be a human carcinogen by the NTP.
Research shows that 1,4-dioxane readily penetrates the skin. 1,4-dioxane is listed as possibly carcinogenic to humans by the International Agency for Research on Cancer (IARC).
It is included on California’s Proposition 65 list of chemicals known or suspected to cause cancer or birth defects.
Ethylene oxide is classified as a known human carcinogen by IARC and listed on California’s Proposition 65 list of chemicals known or suspected to cause cancer.
Lymphoma and leukemia are the cancers most frequently to be associated with occupational exposure to ethylene oxide.
Data also link ethylene oxide to breast cancer.
Reproductive toxicity: Ethylene oxide is listed on Prop 65 list as a developmental toxicant and a male and female reproductive toxicant. Other reviews have found ethylene oxide to be a reproductive toxin in male and female rats resulting in decreased fertility, increased fetal deaths, and heritable chromosomal translocations. A study found that inhalation of ethylene oxide at low concentrations affected the development of sperm in rats.
Short-term exposure to 1,4-dioxane may result in nausea, drowsiness, headache, and irritation of the eyes, nose and throat.
Long-term exposure may result in dermatitis, eczema, drying and cracking of skin and liver and kidney damage.
1,4-dioxane and ethylene oxide are prohibited for use in cosmetics products in Canada. The European Union has also prohibited use of ethylene oxide in cosmetic products.
https://www.safecosmetics.org/get-the-facts/chemicals-of-concern/ethoxylated-ingredients/#:~:text=A%20study%20found%20that%20inhalation,the%20eyes%2C%20nose%20and%20throat.
The compound 1,4-dioxane is a trace contaminant in some cosmetic products. It is not used as an ingredient in cosmetics, but may be present in extremely small amounts in some cosmetics. 1,4-dioxane forms as a byproduct during the manufacturing process of certain cosmetic ingredients. These ingredients include certain detergents, foaming agents, emulsifiers and solvents identifiable by the prefix, word, or syllables "PEG," "Polyethylene," "Polyethylene glycol," "Polyoxyethylene," "-eth-," or "-oxynol-."
https://www.fda.gov/cosmetics/potential-contaminants-cosmetics/14-dioxane-cosmetics-manufacturing-byproduct
N,N-Diethylacetamide
(Compound) :
Warning
GHS Hazard Statements
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
H312 (88.64%): Harmful in contact with skin [Warning Acute toxicity, dermal]
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H332 (88.64%): Harmful if inhaled [Warning Acute toxicity, inhalation]
H335 (88.64%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Hazard Classes and Categories
Acute Tox. 4 (100%)
Acute Tox. 4 (88.64%)
Skin Irrit. 2 (100%)
Eye Irrit. 2A (100%)
Acute Tox. 4 (88.64%)
STOT SE 3 (88.64%)
THE CARCINOGENIC ACTIVITY OF DIETHYLACETAMIDE WAS STUDIED BECAUSE OF ITS ABILITY TO DENATURE PROTEINS & STRUCTURAL RESEMBLANCE TO NITROSAMINE DERIVATIVES. INGESTED, IT PRODUCED A TRANSITIONAL CELL CARCINOMA OF RAT KIDNEY & SEVERE RENAL DAMAGE. EVIDENCE DOES NOT SUPPORT THE VIEW THAT CYCLIC NITROSAMINES EXERT THEIR CARCINOGENIC ACTION VIA METAB TO DIAZOALKANES.
N,N-DIETHYLACETAMIDE 600 MG/KG GIVEN TO PREGNANT RATS ON THE 13TH OR 14TH DAYS OF GESTATION PRODUCED DIAPLACENTAL TERATOGENIC EFFECTS. THIS WAS 40% OF THE LD50 DOSE.
CMPDS INCLUDING N,N-DIETHYLACETAMIDE SHOWED NONSPECIFIC SPASMOLYTIC PROPERTIES AGAINST HISTAMINE-, CARBACHOL-, & BARIUM CHLORIDE-INDUCED SPASMS IN ISOLATED GUINEA PIG ILEUM, & AT LOW IV DOSES AFFECTED THE HEART RATE & BLOOD PRESSURE IN RATS, CATS, & DOGS.
INJECTIONS OF N,N-DIETHYLACETAMIDE INDUCED SOME JUMPS OF CONVULSIONS IN MICE. IT INDUCED TESTICULAR ATROPHY IN RATS. RATS GIVEN 1/20 LD50 DOSES DAILY FOR 6 WK DID NOT EXHIBIT TOXIC EFFECTS BUT DID EXHIBIT DECREASED PONDERAL GROWTH.
https://pubchem.ncbi.nlm.nih.gov/compound/N_N-Diethylacetamide#section=Hazards-Identification
1,2-Distearoyl-sn-glycero-3- phosphocholine :
Synonyms:
1,2-distearoyl-sn-glycero-3-phosphatidylcholine; Coatsome MC 8080;
1,2-Distearoyl-sn-glycero-3-Phosphocholine; 1,2-DSPC;
Relevant identified uses: For research use only, not for human or veterinary use.
Material may be irritating to the mucous membranes and upper respiratory tract.
May be harmful by inhalation, ingestion, or skin absorption.
May cause eye, skin, or respiratory system irritation.
To the best of our knowledge, the toxicological properties have not been thoroughly investigated.
In Case of Ingestion:
Wash out mouth with water provided person is conscious. Never give anything by mouth to an
unconscious person. Get medical attention. Do NOT induce vomiting unless directed to do so by
medical personnel.
Containment and Cleaning Up:
Transfer to a chemical waste container for disposal in accordance with local regulations
Hazardous Decomposition or Byproducts:
carbon dioxide
carbon monoxide
nitrogen oxides
phosphorous oxides
Information on The toxicological effects of this product have not been thoroughly studied.
https://www.caymanchem.com/msdss/15100m.pdf
Potassium Chloride :
Upset stomach, nausea, vomiting, gas, or diarrhea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Cautions with Oral use:
cardiac disease; elderly; hiatus hernia (with modified-release preparations); history of peptic ulcer (with modified-release preparations); intestinal stricture (with modified-release preparations)
Side effects:
Hyperkalaemia (Potassium overdose)
abdominal cramps; diarrhoea; gastrointestinal disorders; nausea; vomiting.
https://bnf.nice.org.uk/drug/potassium-chloride.html
Monobasic potassium phosphate :
Potential Health Effects
Eye: Dust may cause mechanical irritation.
Skin: May cause skin irritation. Low hazard for usual industrial handling.
Ingestion: May cause irritation of the digestive tract. Low hazard for usual industrial handling.
Inhalation: May cause respiratory tract irritation.
Chronic: Ingestion of large doses may cause nausea, vomiting, diarrhea. Chronic exposure to this product may cause calcium phosphate deposition in the kidneys.
Persons with impaired kidney function may be more susceptible to the effects of this substance. Treat symptomatically and supportively
https://fscimage.fishersci.com/msds/19543.htm
Toxic to terrestrial vertebrates
https://www.fishersci.co.uk/chemicalProductData_uk/wercs?itemCode=12694957&lang=EN
Dibasic sodium phosphate dihydrate :
Ingredients:
Sodium phosphate dibasic (listed beneath),
Phosphoric acid :
Phosphoric Acid can affect you when breathed in.
* Phosphoric Acid is a CORROSIVE CHEMICAL and contact can irritate and burn the eyes.
* Breathing Phosphoric Acid can irritate the nose, throat and lungs causing coughing and wheezing.
* Long-term exposure to the liquid may cause drying and cracking of the skin.
* Phosphoric Acid is on the Hazardous Substance List because it is regulated by OSHA and cited by ACGIH, DOT, NIOSH, IRIS, NFPA and EPA.
* This chemical is on the Special Health Hazard Substance List because it is CORROSIVE.
Acute Health Effects
The following acute (short-term) health effects may occur immediately or shortly after exposure to Phosphoric Acid:
* Contact can irritate and burn the eyes.
* Breathing Phosphoric Acid can irritate the nose and throat causing coughing and wheezing.
Chronic Health Effects
The following chronic (long-term) health effects can occur at some time after exposure to Phosphoric Acid and can last for months or years:
Cancer Hazard
* According to the information presently available to the New Jersey Department of Health and Senior Services, Phosphoric Acid has not been tested for its ability to cause cancer in animals.
Reproductive Hazard
* According to the information presently available to the New Jersey Department of Health and Senior Services, Phosphoric Acid has not been tested for its ability to affect reproduction.
Other Long-Term Effects
* Phosphoric Acid can irritate the lungs. Repeated exposure may cause bronchitis to develop with cough, phlegm, and/or shortness of breath.
* Long-term exposure to the liquid may cause drying and cracking of the skin
https://www.nj.gov/health/eoh/rtkweb/documents/fs/1516.pdf
Disodium salt dihydrate :
Substance name : EDTA, Disodium, Dihydrate.
synonyms : Ethylenediaminetetraacetic acid, disodium salt, dihydrate
Restrictions on use : Not for food, drug or household use
GHS US classification
Acute toxicity (oral) Category 4 H302 Harmful if swallowed
Skin corrosion/irritation Category 2 H315 Causes skin irritation
Serious eye damage/eye irritation Category 2A H319 Causes serious eye irritation
Specific target organ toxicity (single exposure) Category 3 H335 May cause respiratory irritation
Hazard statements (GHS US) : H302 - Harmful if swallowed
H315 - Causes skin irritation
H319 - Causes serious eye irritation
H335 - May cause respiratory irritation
Precautionary statements (GHS US) : P261 - Avoid breathing dust.
P264 - Wash exposed skin thoroughly after handling.
P270 - Do not eat, drink or smoke when using this product.
P271 - Use only outdoors or in a well-ventilated area.
P280 - Wear eye protection, protective gloves.
P301+P330+P331 - IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302+P352 - IF ON SKIN: Wash with plenty of soap and water.
P311 - Call a POISON CENTER or doctor/physician.
P305+P351+P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P332+P313 - If skin irritation occurs: Get medical advice/attention.
P337+P313 - If eye irritation persists: Get medical advice/attention
http://www.affymetrix.com/support/technical/usb/msds/15699A.pdf
Dibasic sodium phosphate dihydrate / Sodium phosphate dibasic (whole product) :
Ingestion :
Do NOT induce vomiting. Get medical attention
Hazardous Combustion Products:
Oxides of phosphorus, Phosphorus trihydride (phosphine), Sodium oxides.
7.1. Precautions for safe handling
Avoid contact with skin and eyes. Do not breathe dust. Do not ingest. If swallowed then seek immediate medical assistance. Minimize dust generation and accumulation. Wash hands before breaks and immediately after handling the product
The toxicological properties have not been fully investigated.
https://www.fishersci.co.uk/chemicalProductData_uk/wercs?itemCode=12644977&lang=EN
Sodium phosphate dibasic is on the Hazardous Substance list because it is cited by DOT and EPA.
Has not been tested for reproductive harm.
https://nj.gov/health/eoh/rtkweb/documents/fs/1723.pdf
Mild toxicity recorded in Rat trials.
https://fscimage.fishersci.com/msds/01999.htm
EMERGENCY OVERVIEW RISK:
Irritating to eyes, respiratory system and skin
FLAMMABILITY 0 HEALTH HAZARD 2 INSTABILITY 0
SWALLOWED:
Accidental ingestion of the material may be damaging to the health of the individual.
As absorption of phosphates from the bowel is poor, poisoning this way is less likely. Effects can include vomiting, tiredness,
fever, diarrhea, low blood pressure, slow pulse, cyanosis, spasms of the wrist, coma and severe body spasms.
EYE
Evidence exists, or practical experience predicts, that the material may cause eye irritation in a substantial number of individuals.
Prolonged eye contact may cause inflammation characterized by a temporary redness of the conjunctiva (similar to windburn).
Alkaline salts may be intensely irritating to the eyes and precautions should be taken to ensure direct eye contact is avoided.
SKIN
The material may cause mild but significant inflammation of the skin either following direct contact or after a delay of some
time. Repeated exposure can cause contact dermatitis which is characterized by redness, swelling and blistering.
Skin contact is not thought to have harmful health effects, however the material may still produce health damage following entry through wounds, lesions or abrasions..
Open cuts, abraded or irritated skin should not be exposed to this material.
Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects.
Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.
INHALED
The material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage.
Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.
CHRONIC HEALTH EFFECTS
Long-term exposure to respiratory irritants may result in disease of the airways involving difficult breathing and related systemic problems.
Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving
organs or biochemical systems.
Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung. Prime symptom is breathlessness; lung shadows show on X-ray.
Sodium phosphate dibasic can cause stones in the kidney, loss of mineral from the bones and loss of thyroid gland function.
Asthma-like symptoms may continue for months or even years after exposure to the material ceases. This may be due to a non-allergenic condition known as reactive airways dysfunction syndrome (RADS) which can occur following exposure to high levels of highly irritating compound. Key criteria for the diagnosis of RADS include the absence of preceding respiratory disease, in a non-atopic individual, with abrupt onset of persistent asthma-like symptoms within minutes to hours of a documented exposure to the irritant. A reversible airflow pattern, on spirometry, with the presence of moderate to severe bronchial hyperreactivity on methacholine challenge testing and the lack of minimal lymphocytic inflammation, without eosinophilia, have also been included in the criteria for diagnosis of RADS. RADS (or asthma) following an irritating inhalation is an infrequent disorder with rates related to the concentration of and duration of exposure to the irritating substance.
Industrial bronchitis, on the other hand, is a disorder that occurs as result of exposure due to high concentrations of irritating
substance (often particulate in nature) and is completely reversible after exposure ceases. The disorder is characterised by dyspnea, cough and mucus production.
The material may be irritating to the eye, with prolonged contact causing inflammation. Repeated or prolonged exposure to irritants may produce conjunctivitis.
The material may cause skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the production of vesicles, scaling and thickening of the skin.
https://datasheets.scbt.com/sc-236917.pdf
Full list of Ingredients;
ALC-0315 = (4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate)
ALC-0159 = 2[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide
1,2-Distearoyl-sn-glycero-3-phosphocholine
cholesterol
potassium chloride
potassium dihydrogen phosphate
sodium chloride
disodium hydrogen phosphate dihydrate
sucrose
water for injections
https://www.gov.uk/government/publications/regulatory-approval-of-pfizer-biontech-vaccine-for-covid-19/information-for-uk-recipients-on-pfizerbiontech-covid-19-vaccine#ingredients
CYANIDE POISONING VIA ACETONITRILE :
mRNA (Needs it's own page).
Lipids including,
4-hydroxybutyl : (Possible cyanide poisoning, see picture at the bottom)
Product Name: 4-fluoro MDMB-BUTINACA N-(4-hydroxybutyl) metabolite
Classification of the Substance or Mixture:
Flammable Liquids, Category 2
Acute Toxicity: Inhalation, Category 4
Acute Toxicity: Oral, Category 4
Acute Toxicity: Skin, Category 4
Serious Eye Damage/Eye Irritation, Category 2
H225: Highly flammable liquid and vapor.
H302: Harmful if swallowed.
H312: Harmful in contact with skin.
H319: Causes serious eye irritation.
H332: Harmful if inhaled.
P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P302+352: IF ON SKIN: Wash with plenty of soap and water.
P303+361+353: IF ON SKIN (or hair): Remove/take off immediately all contaminated clothing. Rinse skin with water/shower.
P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P330: Rinse mouth.
P337+313: If eye irritation persists, get medical advice/attention.
P362+364: Take off contaminated clothing and wash it before reuse
Also contains Acetonitrile (99.0%) (4-fluoro MDMB-BUTINACA N-(4-hydroxybutyl)
metabolite 0.1%)
Acetonitrile is metabolized to cyanide. Patients with significant exposures must be observed for signs of cyanide poisoning and treated accordingly. -https://www.caymanchem.com/msdss/26857m.pdf
Adverse Human Health
Effects and Symptoms
Can cause fatal cyanide poisoning.
Causes serious eye irritation.
Harmful if swallowed, inhaled, or absorbed through the skin.
Material may be irritating to the mucous membranes and upper respiratory tract.
May be fatal if swallowed, inhaled, or absorbed through the skin.
May cause skin or respiratory system irritation.
Several hours may elapse from exposure to onset of symptoms.
To the best of our knowledge, the toxicological properties have not been thoroughly investigated
All above from https://www.caymanchem.com/msdss/26857m.pdf
hexane-6,1-diyl :
Reproductive/Developmental Effects:
No information is available on the reproductive or developmental effects of hexane in humans.
Testicular damage has been observed in male rats exposed to hexane via inhalation.
Teratogenic effects were not observed in the offspring of rats chronically exposed via inhalation in several studies. (3,5,8)
https://www.epa.gov/sites/production/files/2016-09/documents/hexane.pdf
Realistically Hexane in small doses is one of the safer ingredients.
2-hexyldecanoate :
(Product name : Ascorbyl tetra-2-hexyldecanoate)
Not a hazardous substance or mixture according to the Globally Harmonized System (GHS) - https://labchem-wako.fujifilm.com/sds/W01W0101-1959JGHEEN.pdf
(though they also say if ingested, call a physician or poison control center immediately).
Hazard statement(s)
H317 May cause an allergic skin reaction
H410 Very toxic to aquatic life with long lasting effects
In conclusion, there is not much data on this substance.
Poly(ethylene glycol) MW 2000 :
(Polyethylene glycol 2000 / PEG 2000)
It is noticed the current research demonstrated the moderate cytotoxicity of PEG-1000 and PEG-4000 to L929 cells, and the nearly non-cytotoxicity of PEG-400 and PEG-2000
https://pubs.rsc.org/en/content/articlehtml/2017/ra/c7ra00861a
Depending on manufacturing processes, PEGs may be contaminated with measurable amounts of ethylene oxide and 1,4-dioxane. i The International Agency for Research on Cancer classifies ethylene oxide as a known human carcinogen and 1,4-dioxane as a possible human carcinogen. Ethylene oxide can also harm the nervous system ii and the California Environmental Protection Agency has classified it as a developmental toxicant based on evidence that it may interfere with human development. iii 1,4-dioxane is also persistent. In other words, it doesn’t easily degrade and can remain in the environment long after it is rinsed down the shower drain. 1,4-dioxane can be removed from cosmetics during the manufacturing process by vacuum stripping, but there is no easy way for consumers to know whether products containing PEGs have undergone this process.
While carcinogenic contaminants are the primary concern, PEG compounds themselves show some evidence of genotoxicity vi,vii and if used on broken skin can cause irritation and systemic toxicity. The industry panel that reviews the safety of cosmetics ingredients concluded that some PEG compounds are not safe for use on damaged skin (although the assessment generally approved of the use of these chemicals in cosmetics). ix Also, PEG functions as a “penetration enhancer,” increasing the permeability of the skin to allow greater absorption of the product — including harmful ingredients.
Propylene glycol is a related chemical that, like PEGs, functions as a penetration enhancer and can allow harmful ingredients to be absorbed more readily through the skin. It can also cause allergic reactions. Health Canada categorized propylene glycol as a “moderate human health priority” and flagged it future assessment under the government’s Chemicals Management Plan.
Other ethoxylates may be contaminated with ethylene oxide and 1,4-dioxane. These ingredients usually have chemical names including the letters “eth” (e.g., polyethylene glycol).
https://davidsuzuki.org/queen-of-green/dirty-dozen-peg-compounds-contaminants/#:~:text=Depending%20on%20manufacturing%20processes%2C%20PEG,and%201%2C4%2Ddioxane.&text=The%20International%20Agency%20for%20Research,as%20a%20possible%20human%20carcinogen.
Ethoxylation is the process of reacting ethylene oxide with other chemicals to make them less harsh. Ethoxylation can create small amounts of 1,4-dioxane and leave residual ethylene oxide in the product.
This manufacturing process can result in two toxic contaminants linked to breast cancer and other cancers: ethylene oxide and 1,4-dioxane.
Ethoxylated ingredients are generally of low concern on their own. However, they can be contaminated with ethylene oxide, a known carcinogen,and 1,4- dioxane, reasonably anticipated to be a human carcinogen by the NTP.
Research shows that 1,4-dioxane readily penetrates the skin. 1,4-dioxane is listed as possibly carcinogenic to humans by the International Agency for Research on Cancer (IARC).
It is included on California’s Proposition 65 list of chemicals known or suspected to cause cancer or birth defects.
Ethylene oxide is classified as a known human carcinogen by IARC and listed on California’s Proposition 65 list of chemicals known or suspected to cause cancer.
Lymphoma and leukemia are the cancers most frequently to be associated with occupational exposure to ethylene oxide.
Data also link ethylene oxide to breast cancer.
Reproductive toxicity: Ethylene oxide is listed on Prop 65 list as a developmental toxicant and a male and female reproductive toxicant. Other reviews have found ethylene oxide to be a reproductive toxin in male and female rats resulting in decreased fertility, increased fetal deaths, and heritable chromosomal translocations. A study found that inhalation of ethylene oxide at low concentrations affected the development of sperm in rats.
Short-term exposure to 1,4-dioxane may result in nausea, drowsiness, headache, and irritation of the eyes, nose and throat.
Long-term exposure may result in dermatitis, eczema, drying and cracking of skin and liver and kidney damage.
1,4-dioxane and ethylene oxide are prohibited for use in cosmetics products in Canada. The European Union has also prohibited use of ethylene oxide in cosmetic products.
https://www.safecosmetics.org/get-the-facts/chemicals-of-concern/ethoxylated-ingredients/#:~:text=A%20study%20found%20that%20inhalation,the%20eyes%2C%20nose%20and%20throat.
The compound 1,4-dioxane is a trace contaminant in some cosmetic products. It is not used as an ingredient in cosmetics, but may be present in extremely small amounts in some cosmetics. 1,4-dioxane forms as a byproduct during the manufacturing process of certain cosmetic ingredients. These ingredients include certain detergents, foaming agents, emulsifiers and solvents identifiable by the prefix, word, or syllables "PEG," "Polyethylene," "Polyethylene glycol," "Polyoxyethylene," "-eth-," or "-oxynol-."
https://www.fda.gov/cosmetics/potential-contaminants-cosmetics/14-dioxane-cosmetics-manufacturing-byproduct
N,N-Diethylacetamide
(Compound) :
Warning
GHS Hazard Statements
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
H312 (88.64%): Harmful in contact with skin [Warning Acute toxicity, dermal]
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H332 (88.64%): Harmful if inhaled [Warning Acute toxicity, inhalation]
H335 (88.64%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Hazard Classes and Categories
Acute Tox. 4 (100%)
Acute Tox. 4 (88.64%)
Skin Irrit. 2 (100%)
Eye Irrit. 2A (100%)
Acute Tox. 4 (88.64%)
STOT SE 3 (88.64%)
THE CARCINOGENIC ACTIVITY OF DIETHYLACETAMIDE WAS STUDIED BECAUSE OF ITS ABILITY TO DENATURE PROTEINS & STRUCTURAL RESEMBLANCE TO NITROSAMINE DERIVATIVES. INGESTED, IT PRODUCED A TRANSITIONAL CELL CARCINOMA OF RAT KIDNEY & SEVERE RENAL DAMAGE. EVIDENCE DOES NOT SUPPORT THE VIEW THAT CYCLIC NITROSAMINES EXERT THEIR CARCINOGENIC ACTION VIA METAB TO DIAZOALKANES.
N,N-DIETHYLACETAMIDE 600 MG/KG GIVEN TO PREGNANT RATS ON THE 13TH OR 14TH DAYS OF GESTATION PRODUCED DIAPLACENTAL TERATOGENIC EFFECTS. THIS WAS 40% OF THE LD50 DOSE.
CMPDS INCLUDING N,N-DIETHYLACETAMIDE SHOWED NONSPECIFIC SPASMOLYTIC PROPERTIES AGAINST HISTAMINE-, CARBACHOL-, & BARIUM CHLORIDE-INDUCED SPASMS IN ISOLATED GUINEA PIG ILEUM, & AT LOW IV DOSES AFFECTED THE HEART RATE & BLOOD PRESSURE IN RATS, CATS, & DOGS.
INJECTIONS OF N,N-DIETHYLACETAMIDE INDUCED SOME JUMPS OF CONVULSIONS IN MICE. IT INDUCED TESTICULAR ATROPHY IN RATS. RATS GIVEN 1/20 LD50 DOSES DAILY FOR 6 WK DID NOT EXHIBIT TOXIC EFFECTS BUT DID EXHIBIT DECREASED PONDERAL GROWTH.
https://pubchem.ncbi.nlm.nih.gov/compound/N_N-Diethylacetamide#section=Hazards-Identification
1,2-Distearoyl-sn-glycero-3- phosphocholine :
Synonyms:
1,2-distearoyl-sn-glycero-3-phosphatidylcholine; Coatsome MC 8080;
1,2-Distearoyl-sn-glycero-3-Phosphocholine; 1,2-DSPC;
Relevant identified uses: For research use only, not for human or veterinary use.
Material may be irritating to the mucous membranes and upper respiratory tract.
May be harmful by inhalation, ingestion, or skin absorption.
May cause eye, skin, or respiratory system irritation.
To the best of our knowledge, the toxicological properties have not been thoroughly investigated.
In Case of Ingestion:
Wash out mouth with water provided person is conscious. Never give anything by mouth to an
unconscious person. Get medical attention. Do NOT induce vomiting unless directed to do so by
medical personnel.
Containment and Cleaning Up:
Transfer to a chemical waste container for disposal in accordance with local regulations
Hazardous Decomposition or Byproducts:
carbon dioxide
carbon monoxide
nitrogen oxides
phosphorous oxides
Information on The toxicological effects of this product have not been thoroughly studied.
https://www.caymanchem.com/msdss/15100m.pdf
Potassium Chloride :
Upset stomach, nausea, vomiting, gas, or diarrhea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Cautions with Oral use:
cardiac disease; elderly; hiatus hernia (with modified-release preparations); history of peptic ulcer (with modified-release preparations); intestinal stricture (with modified-release preparations)
Side effects:
Hyperkalaemia (Potassium overdose)
abdominal cramps; diarrhoea; gastrointestinal disorders; nausea; vomiting.
https://bnf.nice.org.uk/drug/potassium-chloride.html
Monobasic potassium phosphate :
Potential Health Effects
Eye: Dust may cause mechanical irritation.
Skin: May cause skin irritation. Low hazard for usual industrial handling.
Ingestion: May cause irritation of the digestive tract. Low hazard for usual industrial handling.
Inhalation: May cause respiratory tract irritation.
Chronic: Ingestion of large doses may cause nausea, vomiting, diarrhea. Chronic exposure to this product may cause calcium phosphate deposition in the kidneys.
Persons with impaired kidney function may be more susceptible to the effects of this substance. Treat symptomatically and supportively
https://fscimage.fishersci.com/msds/19543.htm
Toxic to terrestrial vertebrates
https://www.fishersci.co.uk/chemicalProductData_uk/wercs?itemCode=12694957&lang=EN
Dibasic sodium phosphate dihydrate :
Ingredients:
Sodium phosphate dibasic (listed beneath),
Phosphoric acid :
Phosphoric Acid can affect you when breathed in.
* Phosphoric Acid is a CORROSIVE CHEMICAL and contact can irritate and burn the eyes.
* Breathing Phosphoric Acid can irritate the nose, throat and lungs causing coughing and wheezing.
* Long-term exposure to the liquid may cause drying and cracking of the skin.
* Phosphoric Acid is on the Hazardous Substance List because it is regulated by OSHA and cited by ACGIH, DOT, NIOSH, IRIS, NFPA and EPA.
* This chemical is on the Special Health Hazard Substance List because it is CORROSIVE.
Acute Health Effects
The following acute (short-term) health effects may occur immediately or shortly after exposure to Phosphoric Acid:
* Contact can irritate and burn the eyes.
* Breathing Phosphoric Acid can irritate the nose and throat causing coughing and wheezing.
Chronic Health Effects
The following chronic (long-term) health effects can occur at some time after exposure to Phosphoric Acid and can last for months or years:
Cancer Hazard
* According to the information presently available to the New Jersey Department of Health and Senior Services, Phosphoric Acid has not been tested for its ability to cause cancer in animals.
Reproductive Hazard
* According to the information presently available to the New Jersey Department of Health and Senior Services, Phosphoric Acid has not been tested for its ability to affect reproduction.
Other Long-Term Effects
* Phosphoric Acid can irritate the lungs. Repeated exposure may cause bronchitis to develop with cough, phlegm, and/or shortness of breath.
* Long-term exposure to the liquid may cause drying and cracking of the skin
https://www.nj.gov/health/eoh/rtkweb/documents/fs/1516.pdf
Disodium salt dihydrate :
Substance name : EDTA, Disodium, Dihydrate.
synonyms : Ethylenediaminetetraacetic acid, disodium salt, dihydrate
Restrictions on use : Not for food, drug or household use
GHS US classification
Acute toxicity (oral) Category 4 H302 Harmful if swallowed
Skin corrosion/irritation Category 2 H315 Causes skin irritation
Serious eye damage/eye irritation Category 2A H319 Causes serious eye irritation
Specific target organ toxicity (single exposure) Category 3 H335 May cause respiratory irritation
Hazard statements (GHS US) : H302 - Harmful if swallowed
H315 - Causes skin irritation
H319 - Causes serious eye irritation
H335 - May cause respiratory irritation
Precautionary statements (GHS US) : P261 - Avoid breathing dust.
P264 - Wash exposed skin thoroughly after handling.
P270 - Do not eat, drink or smoke when using this product.
P271 - Use only outdoors or in a well-ventilated area.
P280 - Wear eye protection, protective gloves.
P301+P330+P331 - IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302+P352 - IF ON SKIN: Wash with plenty of soap and water.
P311 - Call a POISON CENTER or doctor/physician.
P305+P351+P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P332+P313 - If skin irritation occurs: Get medical advice/attention.
P337+P313 - If eye irritation persists: Get medical advice/attention
http://www.affymetrix.com/support/technical/usb/msds/15699A.pdf
Dibasic sodium phosphate dihydrate / Sodium phosphate dibasic (whole product) :
Ingestion :
Do NOT induce vomiting. Get medical attention
Hazardous Combustion Products:
Oxides of phosphorus, Phosphorus trihydride (phosphine), Sodium oxides.
7.1. Precautions for safe handling
Avoid contact with skin and eyes. Do not breathe dust. Do not ingest. If swallowed then seek immediate medical assistance. Minimize dust generation and accumulation. Wash hands before breaks and immediately after handling the product
The toxicological properties have not been fully investigated.
https://www.fishersci.co.uk/chemicalProductData_uk/wercs?itemCode=12644977&lang=EN
Sodium phosphate dibasic is on the Hazardous Substance list because it is cited by DOT and EPA.
Has not been tested for reproductive harm.
https://nj.gov/health/eoh/rtkweb/documents/fs/1723.pdf
Mild toxicity recorded in Rat trials.
https://fscimage.fishersci.com/msds/01999.htm
EMERGENCY OVERVIEW RISK:
Irritating to eyes, respiratory system and skin
FLAMMABILITY 0 HEALTH HAZARD 2 INSTABILITY 0
SWALLOWED:
Accidental ingestion of the material may be damaging to the health of the individual.
As absorption of phosphates from the bowel is poor, poisoning this way is less likely. Effects can include vomiting, tiredness,
fever, diarrhea, low blood pressure, slow pulse, cyanosis, spasms of the wrist, coma and severe body spasms.
EYE
Evidence exists, or practical experience predicts, that the material may cause eye irritation in a substantial number of individuals.
Prolonged eye contact may cause inflammation characterized by a temporary redness of the conjunctiva (similar to windburn).
Alkaline salts may be intensely irritating to the eyes and precautions should be taken to ensure direct eye contact is avoided.
SKIN
The material may cause mild but significant inflammation of the skin either following direct contact or after a delay of some
time. Repeated exposure can cause contact dermatitis which is characterized by redness, swelling and blistering.
Skin contact is not thought to have harmful health effects, however the material may still produce health damage following entry through wounds, lesions or abrasions..
Open cuts, abraded or irritated skin should not be exposed to this material.
Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects.
Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.
INHALED
The material can cause respiratory irritation in some persons. The body's response to such irritation can cause further lung damage.
Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.
CHRONIC HEALTH EFFECTS
Long-term exposure to respiratory irritants may result in disease of the airways involving difficult breathing and related systemic problems.
Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving
organs or biochemical systems.
Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis; caused by particles less than 0.5 micron penetrating and remaining in the lung. Prime symptom is breathlessness; lung shadows show on X-ray.
Sodium phosphate dibasic can cause stones in the kidney, loss of mineral from the bones and loss of thyroid gland function.
Asthma-like symptoms may continue for months or even years after exposure to the material ceases. This may be due to a non-allergenic condition known as reactive airways dysfunction syndrome (RADS) which can occur following exposure to high levels of highly irritating compound. Key criteria for the diagnosis of RADS include the absence of preceding respiratory disease, in a non-atopic individual, with abrupt onset of persistent asthma-like symptoms within minutes to hours of a documented exposure to the irritant. A reversible airflow pattern, on spirometry, with the presence of moderate to severe bronchial hyperreactivity on methacholine challenge testing and the lack of minimal lymphocytic inflammation, without eosinophilia, have also been included in the criteria for diagnosis of RADS. RADS (or asthma) following an irritating inhalation is an infrequent disorder with rates related to the concentration of and duration of exposure to the irritating substance.
Industrial bronchitis, on the other hand, is a disorder that occurs as result of exposure due to high concentrations of irritating
substance (often particulate in nature) and is completely reversible after exposure ceases. The disorder is characterised by dyspnea, cough and mucus production.
The material may be irritating to the eye, with prolonged contact causing inflammation. Repeated or prolonged exposure to irritants may produce conjunctivitis.
The material may cause skin irritation after prolonged or repeated exposure and may produce on contact skin redness, swelling, the production of vesicles, scaling and thickening of the skin.
https://datasheets.scbt.com/sc-236917.pdf
Full list of Ingredients;
ALC-0315 = (4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate)
ALC-0159 = 2[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide
1,2-Distearoyl-sn-glycero-3-phosphocholine
cholesterol
potassium chloride
potassium dihydrogen phosphate
sodium chloride
disodium hydrogen phosphate dihydrate
sucrose
water for injections
https://www.gov.uk/government/publications/regulatory-approval-of-pfizer-biontech-vaccine-for-covid-19/information-for-uk-recipients-on-pfizerbiontech-covid-19-vaccine#ingredients
CYANIDE POISONING VIA ACETONITRILE :
https://www.caymanchem.com/msdss/26857m.pdf